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KMID : 0350519920450041405
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Journal of Catholic Medical College
1992 Volume.45 No. 4 p.1405 ~ p.1416
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The Effects of Ascorbic Acid on Intraocular Pressure Elevation by Viscoelastic Substance following Intraocular Surgery
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Abstract
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To evaluate the effects of ascoribic acid in lowering intraocular pressure(IOP), IOP, remained radioactivity of 51Cr tagged Healon(r) in an anterior chamber following lens aspiration in rabbit eyes, and ultrastructual changes of trabecular
meshwork
were
observe in time sequence of thirty minutes, one hour, three hours, six hours, twelve hors, first, third, fifth, and seventh day after intravenous injection of ascorbic acid.
The study comprised 40 rabbits divided into two groups: One is Healon(r) injected group following lens aspiration as control group, the other is Healon(r) injected group following lens aspiration and ascorbic acid injection as experimental
group.
@ES The results were as follows:
@EN 1. The average IOPs in experimental group were 21.0*1.87 and 16.2*0.45mmHg on the post operative first and third day respectively. They returned to preoperative level rapidly., While, in control group, the average IOP persisted high level
until
the
postopertive fifth day returned to preoperative IOP level on the seventh day.
2. The average outflow rates of Healon(r) were 22.0 and 37.2% on 30 minutes after injection of 51Crtagged Healon(r) in control and experimental group respectively ; 87.6 and 96.5% on the postoperative third day respectively. On the postoperative
seventh day, both groups were completely outflowed Healon(r). There were significant positive correlations between IOP and radioactivity remaining rate after injection of 51Cr tagged Helaon(r) in control and experimental group.
3. Under scanning electron microscope examination, the control group showed a large amount of Heaon(r) debris in the trabeular meshwork on the postoperative first day, and the most of Healon(r) debris outflowed on the postoperative seventh day.
On
the
other hand, the experimental group showed some inflammatory cells and small amount of Healon(r) debris in the trabecular meshwork on the postoperative first day. No Healon(r) debris was observed on the postoperative third day.
In conclusion, it was suggested that ascorbic acid had prompt effect in lowering intraocular pressure and could prevent intraocular pressure elevation by Healon(r) after intraocular surgery.
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